470002 VO Cardiac safety pharmacology (2017W)
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Details
Sprache: Englisch
Prüfungstermine
Lehrende
Termine
04.12.2017, 09:00 - 11:30, Room 2D 358
06.12.2017, 09:00 - 10:30, Room 2D 358
07.12.2017, 09:00 - 10:30, Room 2D 358
11.12.2017, 09:00 - 10:45, Room 2D 358
12.12.2017, 09:00 - 11:00, Room 2D 358
13.12.2017, 09:00 - 11:00, Room 2D 358
Information
Ziele, Inhalte und Methode der Lehrveranstaltung
In this lecture series (MolTag) students will learn the incentives of cardiac safety pharmacology, the core battery, ISH7b and E14 guidelines and associated tests, the CiPA initiative, the future of safety pharmacology. Two extensive examples of knowledge gathering in safety pharmacology will be given. Students will prepare for lectures by studying relevant literature in advance.
Art der Leistungskontrolle und erlaubte Hilfsmittel
Mindestanforderungen und Beurteilungsmaßstab
Prüfungsstoff
Lecture 1 (2.5 hours)- November 15, December 4 2017, 09:00 – 11:30,
Basics of cardiac physiology, electrical and mechanical aspectsLecture 2 (1.5 hours) – December 6 2017, 09:00 – 10:30,
An introduction in safety pharmacology, a short history, the need of this discipline, test battery, future developments
https://www.ncbi.nlm.nih.gov/pubmed/28425222
https://www.ncbi.nlm.nih.gov/pubmed/21718297Lecture 3 (1.5 hours) – December 7 2017, 09:00 – 10:30
Students will present their findings on the development and content of the ISH7b and E14 guidelines, and the CiPA initiative (to be prepared by students, evaluation of content and presentation skills in English)
https://www.ncbi.nlm.nih.gov/pubmed/28986101
https://www.ncbi.nlm.nih.gov/pubmed/25379800Lecture 4 (1.75 hours)- December 11 2017, 09:00 – 10:45, 2D 358
The cAVB dog model and development of STV as a biomarker, methoxamine rabbit
https://www.ncbi.nlm.nih.gov/pubmed/28574954
https://www.ncbi.nlm.nih.gov/pubmed/25154623
https://www.ncbi.nlm.nih.gov/pubmed/22609158Lecture 5 (2 hours) – December 12, 2017, 09:00 – 11:00
Target finding. IK1 inhibition by PA-6, development of a new drug? Efficacy and safety
https://www.ncbi.nlm.nih.gov/pubmed/28542844
https://www.ncbi.nlm.nih.gov/pubmed/23625347
https://www.ncbi.nlm.nih.gov/pubmed/22291650
https://www.ncbi.nlm.nih.gov/pubmed/21296684
https://www.ncbi.nlm.nih.gov/pubmed/20180941Lecture 6 (2 hours) – December 13, 2017, 09:00 – 11:00
Chronic exposure to drugs, the example of ion channel trafficking defects.
https://www.ncbi.nlm.nih.gov/pubmed/18059314
https://www.ncbi.nlm.nih.gov/pubmed/23558293
https://www.ncbi.nlm.nih.gov/pubmed/28425222
https://www.ncbi.nlm.nih.gov/pubmed/23192368
Basics of cardiac physiology, electrical and mechanical aspectsLecture 2 (1.5 hours) – December 6 2017, 09:00 – 10:30,
An introduction in safety pharmacology, a short history, the need of this discipline, test battery, future developments
https://www.ncbi.nlm.nih.gov/pubmed/28425222
https://www.ncbi.nlm.nih.gov/pubmed/21718297Lecture 3 (1.5 hours) – December 7 2017, 09:00 – 10:30
Students will present their findings on the development and content of the ISH7b and E14 guidelines, and the CiPA initiative (to be prepared by students, evaluation of content and presentation skills in English)
https://www.ncbi.nlm.nih.gov/pubmed/28986101
https://www.ncbi.nlm.nih.gov/pubmed/25379800Lecture 4 (1.75 hours)- December 11 2017, 09:00 – 10:45, 2D 358
The cAVB dog model and development of STV as a biomarker, methoxamine rabbit
https://www.ncbi.nlm.nih.gov/pubmed/28574954
https://www.ncbi.nlm.nih.gov/pubmed/25154623
https://www.ncbi.nlm.nih.gov/pubmed/22609158Lecture 5 (2 hours) – December 12, 2017, 09:00 – 11:00
Target finding. IK1 inhibition by PA-6, development of a new drug? Efficacy and safety
https://www.ncbi.nlm.nih.gov/pubmed/28542844
https://www.ncbi.nlm.nih.gov/pubmed/23625347
https://www.ncbi.nlm.nih.gov/pubmed/22291650
https://www.ncbi.nlm.nih.gov/pubmed/21296684
https://www.ncbi.nlm.nih.gov/pubmed/20180941Lecture 6 (2 hours) – December 13, 2017, 09:00 – 11:00
Chronic exposure to drugs, the example of ion channel trafficking defects.
https://www.ncbi.nlm.nih.gov/pubmed/18059314
https://www.ncbi.nlm.nih.gov/pubmed/23558293
https://www.ncbi.nlm.nih.gov/pubmed/28425222
https://www.ncbi.nlm.nih.gov/pubmed/23192368
Literatur
Zuordnung im Vorlesungsverzeichnis
Letzte Änderung: Mo 07.09.2020 15:47